Mnova Gears - Fraction Analysis

Automated evaluation of collected elution fractions for decision making

To pool or not to pool? This may be a tricky question when more than one fraction has been collected for your sample during preparative chromatography.

Fraction Analysis will help you answer it quickly by automating the analysis of fractions and suggesting the most appropriate action to take. The tool will evaluate the number and size of peaks present in each fraction, match and assign your target peak, calculate its purity, then score and report the results automatically. After Fraction Analysis, you will be able to quickly review the results dashboard and pass the selected fraction to downstream quality control processes.

Improve your chromatography outcome by taking informed decisions on pooling, or otherwise, the eluate fractions!

This new product is in Beta phase

Fraction Analysis

Benefits

Huge time savings on spectral data analysis and preparation of professional-looking reports with the results
Reduce the risk of pooling a pure eluate fraction with a poor-quality one
Bring insight into the results and decide whether to stick to the suggested action or manually override it

Fraction Analysis

Features

Automated data ingestion, processing, analysis, and report generation
Powerful scoring based on peak number, size, and target mass purity
Flexible analysis options
Color coded dashboards and tables with analysis results
Automatic, data-driven suggestion for subsequent action (to keep and QC, or dispose of or review the elution fraction)
Possibility to override the automatically generated results
Summary CSV output with results that can be used as input files for the next-stage analysis

Automatic pick-up and grouping of spectral datasets for analysis

Chrom Cal is fully integrated in Mnova and therefore can handle spectral datasets and extract the information needed for calculating the calibration curves without the need for data transcription into third party software or spreadsheets.

After data ingestion, Chrom Cal can detect and group the samples from different compounds automatically based on an input csv file, and calibration curves for those compounds can be generated in a single run.

Powerful algorithms to fit calibration curves and evaluate results based on pre-defined quality requirements

Chrom Cal relies on a powerful algorithm to process spectral data, integrate compound peaks, and fit the calibration curve to the data points in a fully automated fashion.

Acceptance criteria, such as R2 value threshold or slope range, and cross-validation rules can be pre-defined in the method and evaluated at the end of the analysis to approve or reject the calibration results. This allows you to keep control over the quality and linearity of the results and speeds up the results reviewing process.

Live results in tables and plots

Calibration and validation results are displayed in a result viewer that allows both global and more detailed review of the data.

You can easily navigate between compounds to check the standard curve plots and parameters. Each data point on the graph is dynamically linked to the results tables and spectra. You can zoom in or out on the plot, include or exclude samples from the analysis, or even correct peak assignment or integration when needed, and the results are automatically recalculated.

Multiple analysis output nicely generated and organized

Automatic CSV, Mnova, and PDF reports are generated with the calibration and validation results for each compound and are saved in the chosen location on your disks or databases along with a global HTML report and other metadata, log, and settings files. This saves a lot of time and considerably improves data management practices within your organization as it makes data easily findable and reusable.

Compound calibration results are also included in “.json” files that can feed downstream quantitative analyses performed by other Mgears plugins or by external software. Calibration values are extracted from these files and used for quantitation with no need for manual transcription, an error-prone and time-consuming task.

More Automation

Purification Workflow

Looking for an enterprise-level solution for improving your purification and data management procedures? Check the Best Method and Quality Control bricks that also run in full automation, and learn more about our automated databasing solution with Mgears. You have the complete flexibility to combine and adapt these solutions to your standard procedures to reap even more benefits for your organization.

Academic, Government & Industrial

Markets

Who should be using Fraction Analysis?

Organic chemists, analysts, QC experts, and researchers using quantitative chromatographic methods for quality control, concentration/purity determination, or monitoring/optimization of reactions in one of the following markets and applications:

Pharmaceutical/Drug development industry
Food & Beverage industries
Personal care and Cosmetics
Fine chemical synthesis industries
Polymer industries
Academic research laboratories
Contract Research Organizations (CROs) offering purification services

Compound purification for subsequent use in studies or commercialization
Isolation of unknown impurities in finished products, natural products, or in the environment for structural disclosure, study, etc.
Chiral separation to remove unwanted enantiomers obtained during organic synthesis

Learn & Support

Mnova Gears – Fraction Analysis

Automated evaluation of collected elution fractions for decision making

THIS NEW PRODUCT IS IN BETA PHASE!

Benefits

Help & Resources

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