Automated LC-MS Quality Control of DNA Labeling Reactions
Effectively managing and assessing LC-MS data for the characterization and quality control of DNA Encoded Libraries (DELs) can pose a substantial challenge, especially as the library size expands.
QC Profiling is an automated solution designed to streamline the analysis and quality control assessment of reactions involved in DEL generation. This powerful plugin enables high-throughput processing, analysis, and reporting of LC-MS results. It serves to assess the composition of the reaction-generated DEL mixture, confirm the presence of desired product, and identify any impurities.
Input your worklist as a CSV file and configure the output according to your preferences. Obtain results swiftly and conduct efficient quality control with the intuitive color warning system integrated into the Viewer!
- Incorporate and customize your input seamlessly using a CSV file. Add and organize input into groups, to facilitate the generation of comprehensive results for each group.
- Leverage default templates for reporting the results or craft your unique report layout. Incorporate the specific columns you need into the CSV output for comprehensive reporting.
- Streamline the process of deconvoluting spectra and matching the primary components of UV peaks.
- Quickly identify and label noisy chromatograms for easy review and further action.
- Exclude residual chromatogram peaks from purity calculations to ensure accuracy.
- Identify UV peaks stemming from low molecular weight impurities that require exclusion from quantification, ensuring precise results.
- Effortlessly review your analysis results within the Mnova interface. With the Mgears and the QC Profiling Result Viewers, you can conveniently access and assess all critical results on a single screen.
- Visualize your results with colored charts and instantly spot control flags and warnings for efficient review by exception.
- Append comments to your results and save them directly to the output CSV file.
- Modify your analysis on-the-fly by adding or removing masses as you review the results and launch recalculations.
Academic, Government & Industrial
Who should be using QC Profiling?
- Pharmaceutical, chemical industries, research, and QC environments
- Process chemistry
- Pharmaceutical compound libraries
- Suitable for individual users, research groups as well as large institutions and companies