Quantifying Wittig Reaction Stereoselectivity using 60 MHz Benchtop NMR Spectroscopy
About the speaker
Dr. Susanne Riegel gave a webinar explaining how to quantify Wittig reaction stereoselectivity using a 60MHz benchtop spectrometer.
Abstract
The Wittig Reaction is a reliable, high-yield method for synthesizing alkenes. It is employed in a variety of applications, including agrochemicals, steroidal production, textiles/dyes, synthetic nutritional supplements, because, unlike other alkene-forming synthetic protocols, the Wittig reaction is highly stereoselective. Moreover, this stereoselectivity can be regulated through skillful choice of the Wittig reagent used. Here we describe the synthesis of flavor and aroma compounds through the Wittig reaction and use a 60 MHz benchtop NMR spectrometer to assign and quantify the relative proportion of cis– and trans- isomer formed. 
