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JEOL RESONANCE Inc. and Mestrelab Research S.L. announce a new technology partnership of significant interest to industrial and government institutions that have an interest in compound quantitation using NMR (qNMR).
qNMR has been attracting considerable attention across a broad spectrum of chemical analytical laboratories, as it provides accurate quantitative information without the requirement of reference compounds and determined response factors for every analyte. qNMR can be applied for the evaluation of reference materials and is a primary reference analysis method as judged by European, American, and Japan’s regulatory standards, such as the Japanese Pharmacopoeia.
Intense interest in qNMR is seen at quality control facilities of chemical and pharmaceutical industries as it becomes more widely implemented and understood.
In routine quality control analysis, many samples must be measured and analyzed efficiently and effectively. Even analysts with little or no technical experience with NMR should be able to analyse and evaluate the measurement outcome. For this purpose, a new product should be capable of full, automatic qNMR analysis. JEOL and Mestrelab are developing an integrated and fully automated signal acquisition and qNMR analysis system which will provide the full power of correctly executed qNMR to all users in a single, highly automated environment. A first prototype of this new product will be introduced at the EUROMAR conference in Warsaw, Poland, in July, 2017.
Mr. Santi Dominguez, CEO of Mestrelab Research S.L. stated: “We are very excited by this joint project to bring a fully automated qNMR solution to the market. Our business philosophy is to work with all instrumentation vendors in NMR to provide advanced software solutions which enhance the usability and adoption of NMR as a mainstream analysis technique. qNMR is an ideal example of a business critical application in which the close integration of hardware and software systems can make the technique available to a community of users who have, to date, not been able to access NMR due to its perceived complexity. JEOL is a major NMR instrument manufacturer and we value the opportunity to approach this market with a strong, committed partner with strategic objectives similar to ours. We look forward to scientific, development and commercial collaboration and to popularizing NMR as a technical solution to routine industrial problems.”
Mr. Anai, President & Representative Director of JEOL RESONANCE Inc. said: “JEOL has been advancing the promotion of qNMR through collaborative research with institutions and corporations and also working on standardization of qNMR analysis method. We expect the full automated qNMR to be a powerful analytical tool for many researchers and analysts in various fields such as pharmaceutical, food and chemical.”
JEOL Ltd. is a world leader in electron optical equipment and instrumentation for high-end scientific and industrial research and development. Core product groups include electron microscope s (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.
JEOL RESONANCE, Inc.
JEOL Resonance, Inc. was formed from the NMR Division of JEOL Ltd. in 2011. The company’s mission is to develop new technologies, high end products, and new applications. For more information
MESTRELAB RESEARCH S.L.
Mestrelab Research S.L. is a leading software developer, based in Spain and founded in 2004 as a spin-off of the University of Santiago de Compostela. The company’s mission is to develop software solutions which become the universal processing and analysis interface between analytical instrumentation and chemists.
Santiago de Compostela (April 27, 2017)
Origenis – Mestrelab Press Release, worldwide distribution
Munich, Germany – 13 April 2015 – The Spanish scientific software company Mestrelab Research SL and the German Biotechnology company Origenis GmbH announced today that they have entered into a collaboration to jointly develop a set of physic-chemical property prediction plugins for Mestrelab’s software products, which Mestrelab will be responsible for marketing.
The collaboration agreement has been signed following successful proof of concept integration and therefore the path to get these tools to market is expected to be short. The new partners plan to release in excess of 25 different atomic and molecular properties as part of this joint development effort. The collaboration aims to exploit the combination of Mestrelab’s large user base and track record of developing highly popular and widely adopted scientific software tools and of Origenis’ know how and excellence in drug design and in the use of LINGO methods to predict structural properties.
Santi Dominguez, CEO of Mestrelab, commented on the announcement:
‘We are hugely excited by this collaboration. Physico-chemical property prediction is a widely used tool in our current markets, and this has to date been a gap in our product offering. Origenis’ technology in this area is outstanding, and after extensive evaluation we are hugely impressed by its speed and accuracy. This collaboration will allow us not only to fill that gap, but to become the supplier of first-in-class tools for these applications to our growing customer base. The range of properties Origenis can provide is also very exciting, as it will result in our getting to market not only a very high quality but also a very widely applicable set of tools.
We expect to make these predictions available in our current Mnova platform, as well as in our about to be released mobile device, web and SaaS offering. 2015 is going to be our biggest year ever from the perspective of new products, and this collaboration is one of the most exciting opportunities I feel we have. And we expect to get to market rapidly with these tools, with the first set of plugins available no later than Q3.’
Michael Thormann, Managing Director of Origenis, commented:
‘We are very proud to expand our collaboration with Mestrelab. We join our efforts to integrate Origenis’ physico-chemical property predictions, which have a long successful internal track record, into Mestrelab’s excellent scientific software products. Our range of valuable physico-chemical property prediction tools will now be part of their user-friendly and broadly used Mnova software suite. With Mestrelab’s large user base in over 100 countries precise property prediction will then be available worldwide for scientists in Academia, Biotech, and Pharma.’
Download the pdf of the release here.
Octopus – “pulpo” in Galician – is a favourite dish in Galicia, the home of Mestrelab. If you were fortunate to come to SMASH 2013, you would surely have tasted this local delicacy. The secret to cooking pulpo is to get it soft and flavoursome – not chewy. This can be done done, and there are hundreds of family recipes that prescribe how to get it “just right” – all closely guarded, of course: it’s not trivial.
The new generation of bench-top NMR spectrometers (1) promise to herald a new era of precise food analysis. Researchers have shown how these instruments can be used to show horse meat adulteration of beef (2), olive oil adulteration (3), and what’s really in those herbal supplements “for men only” (4). But in Northern Spain, nothing touches a nerve like cooking perfectly the humble octopus!
We were therefore overjoyed to receive a call from one of our small-magnet collaborators with an eye to using our new mixtures analysis product, SMA, to assist with a new project.
The data still need validation, but it appears that there is substantial promise for this hardware-software combination to take the guess-work out of cooking pulpo!
With substantial IP at stake it is not possible to reveal much detail, but that will follow. Briefly, the NMR spectra of the cooking juices clearly show the sugar profile with respect to constituents and polymerisation, and a careful study has resulted in the discovery of the exact profile that indicates soft, perfectly-cooked pulpo. Researchers believe that this scientific approach will be infallible, and a major advance on approaches based on colour and onions – current best practice.
With tapas-style cooking all the rage in trendy bars and dinner parties around the world, there is little surprise that several television “shopping channels” have shown considerable interest.
“We can speculate dieters and healthy eating fanatics using bench-top NMR coupled with Mnova/SMA in ever-increasing numbers”, a famous TV chef, HB, speculated.
We will reveal more on this exciting topic when the IP is in place. Finally, we have not ruled out the possibility of a bespoke instrument just to do this analysis. The name has not been agreed on, but “Perfect Pulpo” has been mooted. The days of “misinformation” recipes (5) must be numbered!
(2) Jakes, W., Gerdova, a., Defernez, M., Watson, a. D., McCallum, C., Limer, E., … Kemsley, E. K. (2015). Authentication of beef versus horse meat using 60MHz 1H NMR spectroscopy. Food Chemistry, 175, 1–9. doi:10.1016/j.foodchem.2014.11.110