Automated LC-MS Quality Control of DNA Labeling Reactions

«This software easily multiplied our productivity by 3, greatly enhancing the reproducibility and drastically reducing the chance of human error»

Roberto Martinez

Senior Scientist – Novartis

QC Profiling

Benefits

• Efficient evaluation of hundreds of DNA conjugate reactions without throughput limits.​

• Enhanced accuracy with automated deconvolution of peaks and precise mass attribution ensuring error-free results.​

• Consistent interpretation of the results minimizing variability between analyses and reducing mental workload.

• Streamlined analyses enabling quick decision-making based on comprehensive data insights.​

QC Profiling

Features

Flexible Input and Output Configuration

• Flexible Input: Seamlessly incorporate and customize input using a CSV file. Add and organize inputs into groups to generate comprehensive results for each group, ensuring efficient, structured data processing.
• Customizable Output: Use default templates for reporting or create a unique layout. Customize the CSV output by including specific columns needed for detailed reporting, tailoring it to your requirements for better data analysis and interpretation.

Robust and Customizable Analysis Algorithms

• Streamlined Spectral Deconvolution: Efficiently deconvolute spectra and match primary components of UV peaks for accurate analysis.
• Noisy Chromatogram Identification: Quickly identify and label noisy chromatograms for easy review and further action.
• Accurate Purity Calculations: Exclude residual chromatogram peaks from purity calculations and identify UV peaks from low molecular weight impurities for precise results.

   

   

Quality Control tests

• Precise QC Criteria: Define quality control thresholds and associate distinct flag colors with each criterion. This setup ensures immediate flagging when a test falls short, allowing for quick issue identification.
• Efficient Review Process: Facilitate a swift review of results to enhance productivity. The intuitive flagging system quickly identifies and assesses quality control issues, streamlining the resolution process. This improves lab productivity and ensures accurate, reliable results.

Streamlined Result Review and Reporting

• Effortless Review: Easily review analysis results within the Mnova interface. With Mgears and QC Profiling Result Viewers, access all critical results on a single screen.
• Visual Results: Visualize results with colored charts and quickly spot control flags and warnings for efficient, exception-based review.
• Comment and Save: Add comments to your results and save them directly to the output CSV file.
• On-the-Fly Modifications: Modify your analysis by adding or removing masses as you review, and launch recalculations as needed.

Help & Resources

Guides

QC Profiling - User Manual Mnova Gears - Manual

QC Profiling

Related Applications

Identification & Quantification

Academic, Government & Industrial

Target Audience

Organic Chemists

Medicinal Chemists

Analytical Chemists

QC Experts

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