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Ligand Screening & Binding

Mnova for Ligand Screening & Binding

Faster drug discovery and development

Mnova supports ligand screening and binding assays in Pharma/Biotech, Structural Biology, and Drug Discovery, by providing advanced tools for automatic NMR and MS data analysis, and enabling efficient screening and binding affinity studies, accelerating the discovery of novel therapeutics.

From high-throughput screening to quantitative binding analysis, Mnova enhances your research capabilities at every step. ​

​Unlock new possibilities in ligand discovery with Mnova.​

Ligand Screening & Binding

What can Mnova do for your ligand and binding screening?

High-Throughput Ligand Screening by 1D NMR

Supporting various experiments including 1H or 19F, single compounds or mixtures, and multiple types of spectra (STD, T1rho, WaterLogsy, CPMG), Mnova Screen ensures efficient data handling and reporting. This tool already used by top pharmaceutical companies, is designed for ligand screening NMR data.

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Advanced 2D NMR Screening

Enhancing lead discovery through efficient batch processing, Mnova 2D Screen identifies binding ligands based on chemical shift perturbations, Mnova Screen 2D processes protein-observed 2D NMR spectra (1H-15N, 1H-13C, HSQC, HMQC), providing an interactive display of batch processing results for comprehensive analysis.

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Affinity Selection Mass Spectrometry (AS-MS)​

Simplify and accelerate AS-MS analysis with our comprehensive suite of features that ensure precision and efficiency. Affinity Screen automates data processing and binding assessment, accelerating the comprehension of protein/RNA/DNA-ligand interactions and expediting the transition to hit validation and optimization. No need to sift through irrelevant data. Quickly spot the wells with positive binding to review potential promising leads with ease.​

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Quantitative Binding Analysis by NMR

Specializing in chemical shift perturbation analysis for fragment-based drug discovery, Mnova Binding processes 2D HSQC spectra, tracks peak movements, computes dissociation constants (Kd’s), and carries out statistical analysis. This tool integrates with third-party software like AFFINImeter for advanced binding isotherm analysis using different models.

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