Quantitative Analysis of Target–ligand interactions by CSP NMR titrations
A powerful tool that automatically processes 1D and 2D NMR Target-ligand titration spectra, tracks peaks movement, generates the binding curves and calculates values for 1:1 complexes. For a more sophisticated analysis, the binding curves are directly exported to the 3rd party software AFFINImeter, allowing global analysis to a variety of binding models. .
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AFFINImeter for Nuclear Magnetic Resonance allows the advanced analysis of binding isotherms from 2D NMR titrations to measure binding constants (KA). The binding isotherms are imported directly from the software Mnova and a series of advanced tools are available in AFFINImeter-NMR to get the most out of your NMR data including:
Intuitive workflow that allows you to analyze CSP titration experiments interactively or fully automatically.
Automatic peak tracking, binding curve generation and fitting to compute dissociation constant (Kd) of 1:1 complexes.
Easy exporting of binding curves to the 3rd party software AFFINImeter for advanced analyses, e.g, global analysis of a set of titration curves and availability of a variety of binding models.
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