Quantitative analysis via NMR for concentration and purity/potency determination

qGSD (quantitative Global Spectral Deconvolution) algorithm combines the power of deconvolution techniques to handle overlapped signals with the robustness of sum integration of isolated resonances but with the ability to deal efficiently with overlapped peaks.

qGSD provides highly accurate integrals such as those determined by sum integration for very well resolved signals but with the resolving power that comes from GSD, together with access to an analysis capability of partially overlapping signals.

Configure concentration and purification methods using a “concentration conversion factor” (CCF), an artificial signal, or the residual solvent signal with a score threshold. Automatically adjust for changes in receiver gain or scan numbers as needed.

Enhance efficiency by standardizing operations for replicates, making them suitable for SOP implementation by experts and easy reuse by non-experts—ideal for QC workflows in controlled environments.

Mnova qNMR applies optimal settings to calculate compound’s purity which allows users to save precious time on analysis configuration.

This feature firstly will find your parameters (molecular weight, sample weight, reference compound etc.) Then it will apply optimized settings to carry out the NMR analysis and finally calculate your compounds purity.

Whether you’re using Mnova Gears or MyGears automation suite depending on your work environment, you can use one or even several of the automation bricks.

The Gears Concentration brick allows an automated and controlled extraction of compound concentration from batch NMR data, either in libraries or during data acquisition

The Gears Purity brick calculates the potency of an API based on an internal reference standard.