Automatic analysis tool for ligand screening NMR data
Mnova Screen is a simple, efficient tool with flexible analysis and reporting features, trusted by top pharmaceutical companies. It handles data from various screening experiments, including 1H or 19F, single compounds or mixtures, with or without reference spectra, and multiple spectra types.
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15.0.1
15.0.1
15.0.1
Pattern recognition algorithms map your experimental data.
Considers the use of STD, wLOGSY, T1rho, CMPG experiments.
Uses deconvolution to effectively pick peak even weak signals.
Result viewer to quickly inspect your hits.
Export metrics of your analysis into your favorite statistical package.
Handles all kinds of screening data
Mnova Screen gives a great versatility in the choice of screening experiments
Data Organization for batch processing
Ability to read Bruker FBS output (master data file) for seamless data input exchange
19F Automatic hit detection based on intensity changes
Results of 19F screening of a mixture of 20 ligands using the CPMG experiments of ligands without protein ligands with protein and ligands with protein and inhibitor.
Mnova Screen - Overview
Fragment-Based Drug Discovery (FBDD) Application | Webinar
Webinar Series - Mnova Software Tools for Fragment-Based Drug Discovery
Workshop - Mnova Screen
Several groups in Novartis use NMR binding assays to find and validate hits during the early stages of drug discovery. They use ligand-observed NMR experiments such as STD, T1ρ, and CPMG to identify library compounds that interact with a target protein.
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