Enabling fast Pseudo-2D NMR Acquisition for Broadband Homonuclear Decoupling – The EXACT NMR approach
| Title: | Enabling fast Pseudo-2D NMR Acquisition for Broadband Homonuclear Decoupling – The EXACT NMR approach |
| Authors: | Ikenna Ndukwe, Alexandra Shchukina, Vadim Zorin, Carlos Cobas, Krzysztof Kazimierczuk, Craig Butts |
| Date: | 30 May 2017 |
| Reference: |
ChemPhysChem – |
| DOI: | 10.1002/cphc.201700474 |
| Download link: | http://onlinelibrary.wiley.com/doi/10.1002/cphc.201700474/full |
ABSTRACT
Pseudo-2D NMR provides a means of acquiring broadband homonuclear decoupled spectra useful for structural characterization of complex molecules. However, data points concatenated in the direct dimension in these experiments are acquired over incremented time periods – leading to long acquisition times with no sensitivity benefits due to the absence of signals averaging between scans. Herein, the concept of EXACT NMR (‘burst’ non-uniform sampling of data points) is explored in pseudo-2D experiments with results revealing little or no loss in spectral quality or signal intensity despite the acceleration of acquisition – up to 400% in some cases.
Related posts
In vivo NMR is evolving into an important tool to understand biological processes and environmental responses. Current approaches use flow systems to sustain the organisms with oxygenated water and food (e.g., algae) inside the NMR.
Spectroscopic techniques, particularly NMR, frequently encounter the challenge of overlapping peaks. Thus, the need to enhance the resolution of such spectra has been the subject of extensive research for decades
Play FID is a new tool included within the latest version of Mnova 15.0.1. The purpose of Play FID is to provide an auditory representation of NMR data, enhancing the interpretation and understanding of NMR spectra.