Fast multidimensional localized parallel NMR spectroscopy for the analysis of samples
| Title: | Fast multidimensional localized parallel NMR spectroscopy for the analysis of samples |
| Authors: | M. Vega-Vazquez , J. C. Cobas, M. Martin-Pastor |
| Date: | 2010/07/26 |
| Reference: | 48(10):749-52 Magn. Reson. Chem. In press, 2010. |
| DOI: | http://dx.doi.org/10.1002/mrc.2659 |
| Download link: | http://www.ncbi.nlm.nih.gov/pubmed/20661940 |
A parallel localized spectroscopy (PALSY) method is presented to speed up the acquisition of multidimensional NMR (nD) spectra.
A parallel localized spectroscopy (PALSY) method is presented to speed up the acquisition of multidimensional NMR (nD) spectra. The sample is virtually divided into a discrete number of nonoverlapping slices that relax independently during consecutive scans of the experiment, affording a substantial reduction in the interscan relaxation delay and the total experiment time.
PALSY was tested for the acquisition of three experiments 2D COSY, 2D DQF-COSY and 2D TQF-COSY in parallel, affording a time-saving factor of 3–4. Some unique advantages are that the achievable resolution in any dimension is not compromised in any way: it uses conventional NMR data processing, it is not prone to generate spectral artifacts, and once calibrated, it can be used routinely with these and other combinations of NMR spectra. Copyright © 2010 John Wiley & Sons, Ltd.
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