Pseudo-2D NMR provides a means of acquiring broadband homonuclear decoupled spectra useful for structural characterization of complex molecules.
Several groups in Novartis use NMR binding assays to find and validate hits during the early stages of drug discovery. They use ligand-observed NMR experiments such as STD, T1ρ, and CPMG to identify library compounds that interact with a target protein.
Computer-assisted methods development (CAMD) of LC (liquid chromatography) separations comprises the strategies, methodologies, and software that can be used for more effective and efficient development of separations needed in the analytical chromatography laboratory.
A user-friendly NMR interface for the visual and accurate determination of experimental one-bond proton-carbon coupling constants (1JCH) in small molecules is presented.
The trends towards rapid NMR data acquisition, automated NMR spectrum analysis, and data processing and analysis by more naïve users combine to place a higher burden on data processing software to automatically process these data.
