Three tetranortriterpenoids were isolated as hemiacetals (the C-23 epimeric xylorumphiins M− O (4−6 )), which could not be purified due to the equilibration of the hemiacetal epimers in solution, hence giving complex spectra. In order to enable purification, compounds were acetylated and the R and S epimers could be separated. However, for these C-23 epimers, use of standard NOESY and ROESY techniques did not permit their differentiation, due to long distances between H-23 and protons from the main skeleton.
Read more
A top Pharma Company with 200 discovery and development chemists and Circa 100,000 sample per annum (With two third party ELNs) with an In-house developed, long standing tool for data delivery to chemists (upkeep – maintenance/bug fixing a challenge), needs simplify access of all chemists to their analytical data, review of the data and re-storage and to enhance the use of analytical data and avoid work repetition through lack of awareness or visibility of previous work.