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Quantitative 1H NMR (qNMR) is a widely applied technique for compound concentration and purity determinations.

A strong case exists for the introduction of burst non-uniform sampling (NUS) in the direct dimension of NMR spectroscopy experiments.

The current Pros and Cons of a processing protocol to generate pure chemical shift NMR spectra using Generalized Indirect Covariance are presented and discussed.

Covariance processing is a versatile processing tool to generate synthetic NMR spectral representations without the need to acquire time-consuming experimental datasets.

I recently had the chance to catch up with qNMR “guru”, friend, and collaborator – Torsten Schönberger (BKA, Germany). After a few “Kölsch” beers, attention naturally […]

Abnormal metabolism is a key tumor hallmark. Proton magnetic resonance spectroscopy (1H-MRS) allows measurement of metabolite concentration that can be utilized to characterize tumor metabolic changes. 1H-MRS measurements of specific metabolites have been implemented in the clinic.

Novel pure shift NMR experiments Pure shift NMR experiments is a current topic of high interest in NMR spectroscopy. Since the pioneer work done by Zangger […]

Dr John Gauvin (DSM, Holland) recently gave an excellent webinar presentation where he compared the errors and accuracy that can be expected when either “sum” or “peaks” (GSD) integration is used

NMR binding assays are routinely applied in hit finding and validation during early stages of drug discovery, particularly for fragment-based lead generation. To this end, compound libraries are screened by ligand-observed NMR experiments such as STD, T1ρ, and CPMG to identify molecules interacting with a target.