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Abnormal metabolism is a key tumor hallmark. Proton magnetic resonance spectroscopy (1H-MRS) allows measurement of metabolite concentration that can be utilized to characterize tumor metabolic changes. 1H-MRS measurements of specific metabolites have been implemented in the clinic.

Novel pure shift NMR experiments Pure shift NMR experiments is a current topic of high interest in NMR spectroscopy. Since the pioneer work done by Zangger […]

Dr John Gauvin (DSM, Holland) recently gave an excellent webinar presentation where he compared the errors and accuracy that can be expected when either “sum” or “peaks” (GSD) integration is used

NMR binding assays are routinely applied in hit finding and validation during early stages of drug discovery, particularly for fragment-based lead generation. To this end, compound libraries are screened by ligand-observed NMR experiments such as STD, T1ρ, and CPMG to identify molecules interacting with a target.

A wide range of analysis types, from manual to assisted or fully automated batch processing, for all your qNMR concentration and purity determinations. READ MORE

John Gauvin, Assistant NMR Scientist  at DSM, Netherlands, gave a free webinar about a statistical comparison made on several quantification techniques using Mnova NMR software.

There is a rapidly growing use of NMR for quantitation (qNMR) and its extension, mixtures analysis. [1] The experiment most commonly used for the purpose is […]

The authors describe methods to quickly acquire NUS-assisted 2D spectra that are suitable for qNMR.

1.- Introduction The automatic analysis of ligand screening experiments requires several conditions to be met, not only the reprocessing must be performed in optimal conditions of […]